49 days in Panama Itinerary

49 days in Panama Itinerary

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Route & dates

49 days in Panama Itinerary

Start: Santa Fe
Drive + Fly:  19​h
1
Panama City
— 21 nights
Fly:  2​h 15​min
2
Bocas Town, Isla Colon
— 5 nights
Fly + shuttle:  3​h
3
Playa Coronado
— 8 nights
shuttle + Fly:  3​h
4
Changuinola
— 8 nights
Drive:  6​h 45​min
5
Santa Fe
— 3 nights
+2
Drive + Fly + Drive:  56​h
End: Santa Fe

21
nights
Panama City

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Explore the numerous day-trip ideas around Panama City: Colon (Fort San Lorenzo, Gatun Locks, & more), Portobelo (Museo de La Real Aduana de Portobelo, Scuba & Snorkeling, & more) and Taboga Island Beaches (in Isla Taboga). There's still lots to do: make a trip to Panama Canal, buy something for everyone on your list at Albrook Mall, delve into the distant past at Panama La Vieja, and explore the striking landscape of Metropolitan National Park.

For where to stay, photos, reviews, and other tourist information, read Panama City trip builder website .

Santa Fe, USA to Panama City is an approximately 19-hour combination of car and flight. Traveling from Santa Fe to Panama City, you'll lose 2 hours due to the time zone difference. Expect warmer temperatures when traveling from Santa Fe in February; daily highs in Panama City reach 89°F and lows reach 76°F. Wrap up your sightseeing on the 7th (Sat) to allow time to travel to Bocas Town.

Things to do in Panama City

Parks Outdoors Tours

Side Trips

Portobelo, Colon, Isla Santa Catalina, Taboga Island Beaches
Find places to stay Feb 15 — Mar 7:
Highlights from your plan
Panama Canal ©
Panama Canal
Amador Causeway (Calzada de Amador) ©

5
nights
Bocas Town, Isla Colon

The colorful and relaxed Bocas Town has a welcoming atmosphere, with the modestly sized urban area showcasing typical Caribbean clapboard houses and home to a mixed community from across the world.
When in Bocas Town, make a side trip to see Playa Bluff in Bluff Beach, approximately 30 minutes away. There's much more to do: see some colorful creatures with a scuba or snorkeling tour, stroll around Parque Nacional Marino Isla Bastimentos, identify plant and animal life at Dolphin Bay Preserve, and look for gifts at Up In The Hill.

For where to stay, more things to do, traveler tips, and more tourist information, read Bocas Town visit planning site .

Fly from Panama City to Bocas Town in 2.5 hours. Alternatively, you can do a combination of flight, bus, and ferry; or do a combination of bus and ferry. Traveling from Panama City in March, you will find days in Bocas Town are little chillier (75°F), and nights are about the same (75°F). Wrap up your sightseeing on the 12th (Thu) early enough to travel to Playa Coronado.

Things to do in Bocas Town

Parks Outdoors Beaches

Side Trips

Playa Bluff, Up In The Hill, Finca Los Monos Botanical Garden
Find places to stay Mar 7 — 12:
Highlights from your plan
Scuba & Snorkeling
Finca Los Monos Botanical Garden ©
Finca Los Monos Botanical Garden
Boca del Drago ©
Boca del Drago

8
nights
Playa Coronado

Playa Coronado ©
Get out of town with these interesting Playa Coronado side-trips: Playa Santa Clara (in Penonome), El Palmar Beach (in San Carlos) and Farallon (Palmer Beach, Farallon Butterflies, & more).

To find reviews, other places to visit, photos, and tourist information, you can read our Playa Coronado road trip site .

You can do a combination of flight and shuttle from Bocas Town to Playa Coronado in 3 hours. Alternatively, you can do a combination of flight and taxi; or do a combination of ferry, taxi, and bus. You'll set off for Changuinola on the 20th (Fri).

Things to do in Playa Coronado

Outdoors Parks Beaches

Side Trips

Farallon, San Carlos, Altos del Maria, Playa Santa Clara, Playa Punta Chame
Find places to stay Mar 12 — 20:
Highlights from your plan
Playa Santa Clara ©
Playa Santa Clara
Vista Mar Golf Beach & Marina ©
Vista Mar Golf Beach & Marina
Mantaraya Golf Club ©
Mantaraya Golf Club

8
nights
Changuinola

Changuinola ©
Changuinola is a city in the Bocas del Toro Province of Panama and seat city of the Changuinola District. Change things up with these side-trips from Changuinola: Boquete (Eco Horqueta, Volcan Baru National Park, & more). Spend the 25th (Wed) exploring nature at La Amistad National Park. And it doesn't end there: get outside with Aamvecona, head off the coast to Isla Pajaros, and explore the activities along Rio San San.

To find photos, ratings, traveler tips, and other tourist information, go to the Changuinola trip itinerary builder site .

Getting from Playa Coronado to Changuinola by combination of shuttle and flight takes about 3 hours. Other options: do a combination of shuttle, flight, ferry, and bus; or drive. You will leave for Santa Fe on the 28th (Sat).

Things to do in Changuinola

Parks Nature Outdoors

Side Trips

Boquete, Bocas del Toro Province
Find places to stay Mar 20 — 28:
Highlights from your plan
Volcan Baru National Park ©
Volcan Baru National Park
The Lost Waterfalls-Boquete ©
The Lost Waterfalls-Boquete

3
nights
Santa Fe

Santa Fe ©
Santa Fe is the name of the capital of the Santa Fe District in the province of Veraguas in Panama. Get out of town with these interesting Santa Fe side-trips: Santiago de Veraguas (Catedral de Santiago Apostol, Playa Santa Catalina, & more). There's more to do: relax in the rural setting at Chon y Maria Organic Farm and admire the sheer force of Bermejo Waterfalls.

For where to stay, traveler tips, maps, and other tourist information, refer to the Santa Fe visit planner.

Getting from Changuinola to Santa Fe by car takes about 7 hours. Other options: take a bus. Cap off your sightseeing on the 31st (Tue) early enough to travel back home.

Things to do in Santa Fe

Parks Outdoors Beaches

Side Trip

Santiago de Veraguas
Find places to stay Mar 28 — 31:
Highlights from your plan
Santiago Mall ©
Santiago Mall

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